This is a thought I've been entertaining for some time, but this week's discussion about Ars Technica's article on Anthropic, as well as the NIH funding freeze, finally prodded me to put it out there.
A core strategic vulnerability that Musk, his hangers-on, and geek culture more broadly haven't cottoned onto yet: Space is 20th-century propaganda. Certainly, there is still worthwhile and inspirational science to be done with space probes and landers; and the terrestrial satellite network won't dwindle in importance. I went to high school with a guy who went on to do his PhD and get into research through working with the first round of micro-satellites. Resources will still be committed to space. But as a core narrative of technical progress to bind a nation together? It's gassed. The idea that "it might be ME up there one day!" persisted through the space shuttle era, but it seems more and more remote. Going back to the moon would be a remake of an old television show, that went off the air because people ended up getting bored with it the first time. Boots on Mars (at least healthy boots with a solid chance to return home) are decades away, even if we start throwing Apollo money at it immediately. The more outlandish ideas like orbital data centers and asteroid mining don't have the same inspirational power, because they are meant to be private enterprises operated by thoroughly unlikeable men who have shackled themselves to a broadly destructive political program.
For better or worse, biotechnology and nanotechnology are the most important technical programs of the 21st century, and by backgrounding this and allowing Trump to threaten funding, the tech oligarchs kowtowing to him right now are undermining themselves. Biotech should be obvious, although regulatory capture and the impulse for rent-seeking will continue to hold it back in the US. I expect even more money to be thrown at nanotechnology manufacturing going into the 2030s, to try to overcome the fact that semiconductor scaling is hitting a wall, although most of what I've seen so far is still pursuing the Drexlerian vision of MEMS emulating larger mechanical systems... which, if it's not explicitly biocompatible, is likely going down a cul-de-sac.
Everybody's looking for a positive vision of the future to sell, to compete with and overcome the fraudulent tech-fascists who lead the industry right now. A program of accessible technology at the juncture of those two fields would not develop overnight, but could be a pathway there. Am I off base here?