No, Gnome is a non-starter for being as mouse negative as it is. You are very heavily supposed to use Gnome with keyboard shortcuts and it will only sometimes begrudgingly allow you to use the mouse.
I also really want to kick the app drawer in the head. Why is it two operations deep? Why can't it be sorted by category like every other Linux app menu?
I would go with Mint Cinnamon, increase font sizes or UI scaling, switch to the Cinnemenu because it offers bigger square icons rather than a tiny list, turn off a lot of its extra features, and put launchers for commonly used applications on the desktop. Configure updates to automatic, and otherwise sand down a few rough edges and I think you're good to go.