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Had this conversation with someone who chose to no longer be at my table after meeting a blind NPC
(files.catbox.moe)
Another player who was at the table during the incident sent me this meme after the problem player in question (they had a history) left the group chat.
Felt like sharing it here because I'm sure more people should keep this kind of thing in mind.
Some, certainly. Assuming D&D, mid-level clerics can restore missing limbs (and, though the spell description doesn't mention them specifically, I would argue ocular, auditory, and spinal injuries as well). So disability due to injury should at least be less common than in the real world.
Congenital issues, on the other hand, are much more difficult. Wish would work, but that's not exactly accessible.
That said, there's considerable potential for the magical equivalent of prostheses and other accessibility devices to be more effective than their real-world counterparts.