this post was submitted on 30 May 2024
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The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.

"We want to do something to help those who are suffering from tooth loss or absence," said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."

Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.

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[–] Spitzspot@lemmings.world 52 points 5 months ago (1 children)

Adult teething products are going to the moon!

[–] ikidd@lemmy.world 15 points 5 months ago

I predict skyrocketing sales of beef jerky. And not that namby-pamby gas station shit that you can bite off with your incisors, the real stuff that you have to chew for 2 hours to soften enough to swallow.

[–] danc4498@lemmy.world 44 points 5 months ago (2 children)

Insurance will probably call this cosmetic and not cover it.

[–] Cosmicomical@lemmy.world 7 points 5 months ago

Something like this seems cheap and longterm enough to be included in an insurance. Maybe not immediately, but soon enough.

[–] Reverendender@sh.itjust.works 43 points 5 months ago* (last edited 5 months ago) (1 children)

Yussss! Finally I will have the ferret teeth I have dreamed of for so long, and the world will be mine for the taking!

Seriously though, since getting my first filling, I have dreamed of being able to regrow teeth! What an age we live in!

[–] CeeBee@lemmy.world 11 points 5 months ago (1 children)

A process called rapid recalcification has existed for almost a decade. I don't understand why it hasn't made its way into dentistry yet.

[–] Promethiel@lemmy.world 20 points 5 months ago* (last edited 5 months ago)

Hard to not be a cynic and assume the ADA (American Dental Association) isn't wholly made up of "the 10th dentist" lobbying against dental progress but...

That is not the only dental care breakthrough that isn't widely available in the US (they're all available and priced for the 'I don't actually need to worry about price tags' crowd, who can also just travel elsewhere) but which would promote healthier lives at the cost of less dentist visits. Curious how it happens.

[–] FluorideMind@lemmy.world 25 points 5 months ago (3 children)

Can't wait for it to be $700 a dose.

[–] mysticpickle@lemmy.ca 39 points 5 months ago

Beat a couple thousand for an implant. Progress!

[–] Mobiuthuselah@lemm.ee 17 points 5 months ago

Me too! That'd be amazing! Forget a root canal. Let's yank it and start over.

[–] Cataphract@lemmy.ml 2 points 5 months ago

Can't believe the dental fluoride lobbyists are already flooding lemmy with disinformation :P.

[–] Khanzarate@lemmy.world 21 points 5 months ago (3 children)

I had my wisdom teeth removed because I failed to take care of them (dumb teenager), but my dentist told me my jaw fit them just fine, so I never had to lose them.

I want them back.

[–] tsonfeir@lemmy.world 8 points 5 months ago (1 children)

No smart teeth for dumb people 😜

[–] Khanzarate@lemmy.world 4 points 5 months ago

I'm not dumb nowwww though. I want them back.

Dentist didn't even let me keep them. I was gonna cast them in resin and make bone dice out of my mistake. Unfortunately, human teeth aren't big enough to make dice without some extra material.

[–] lapping6596@lemmy.world 3 points 5 months ago* (last edited 5 months ago) (2 children)

I had the exact same experience.

I wonder how weird it is to have teeth in the empty flesh spots left there now.

[–] eletes@sh.itjust.works 2 points 5 months ago

I still have mine in in my 30's. I forget about them except when brushing since I don't want a cavity back there. There are a few times where I've actively tried using them and it's hard to tell they're being used

[–] Khanzarate@lemmy.world 1 points 5 months ago

I bet it won't be weird at all, honestly.

Growing pains, obviously, that'd be weird, but once they're in, you'd get used to them as easily as you got used to having them removed.

At least, I had mine for a number of years before they were removed. It seems surprising, but I'm used to not having them, and I think the inverse will be equally weird.

[–] TexasDrunk@lemmy.world 2 points 5 months ago

I lost a lot of teeth due to poor education, bad genes, and well water. I want them all back.

[–] Mouselemming@sh.itjust.works 13 points 5 months ago (2 children)

There's already several comments about how expensive it would be in the US along with dental care in general, but IIRC a lot of other countries leave dentistry out of their health care plans as well. Any country that can foresee this as becoming freely available want to speak up?

[–] brb@sh.itjust.works 12 points 5 months ago (1 children)

In Finland dental care

• is free for students (~70€/year for upper education)

• is free if you are unable to work and have no income

• has payment ceiling of 762€/year for everyone else (other healthcare is included in this also)

Medicine also has payment ceiling of 627€/year after which you pay 2.50€ for any medicine

So not completely free but pretty manageable I would say

[–] Postmortal_Pop@lemmy.world 2 points 5 months ago (1 children)

How does Finland handle naturalization? I'm not well off by any measure but I'm more than happy to jump through every hoop to get out of my shit hole nation.

[–] brb@sh.itjust.works 2 points 5 months ago

I'm not familiar with it but you should find all the info here

https://migri.fi/en/citizenship-for-adults

[–] deraceituno@lemmy.world 8 points 5 months ago

In germany it would probably fall under aesthetics care like implants. Meaning they could eventually cover a portion, but the rest is on u. Was like that for my implant

[–] PineRune@lemmy.world 13 points 5 months ago* (last edited 5 months ago) (1 children)

I had a new tooth start sprouting on the inside of my mouth a while back. The new nerve in it was horribly sensitive, and I thought I had a cracked or damaged tooth before the dentist told me what was going on. I would rather have a nerve-less implant than a new-growing tooth like that again, given the choice.

Edit: It was a random new growth along the outside of my gums in my 20s.

If they can regrow nerves, I think there are some implications that are slightly more exciting than teething...

[–] Raxiel@lemmy.world 9 points 5 months ago* (last edited 5 months ago) (1 children)

Between this and the tooth decay "vaccine" (that replaces acid producing bacteria in the mouth with an alcohol producing kind) there's no reason my kids shouldn't reach old age without a full set of their teeth.
Aside from that whole, climate-change-driven-collapse-of-social -order thing.

I better avoid it through. I had four of my otherwise healthy adult teeth removed early on to avoid crowding issues. No idea where they'd fit in my head now if they grew back

[–] Zron@lemmy.world 4 points 5 months ago (1 children)

So now instead of getting plaque, I’ll just get tipsy on my saliva? And no one told me?

[–] Siegfried@lemmy.world 6 points 5 months ago

Stop eating candy! You will get drunk!

flying chancla

[–] Godnroc@lemmy.world 5 points 5 months ago (4 children)

Tooth growth putting! Absolutely no way that could cause horrors!

[–] mynachmadarch@kbin.social 7 points 5 months ago

That movie "Teeth" is about to have a resurgence of watchers I bet.

[–] werefreeatlast@lemmy.world 1 points 5 months ago (1 children)

My nose teeth could come in handy. So would anus teeth. I never had anus teeth, but I've plugged many a toilet. Imagine that never happening again to anyone! Just add 3 or 4 molars there and away we go!

[–] Nelots@lemm.ee 2 points 5 months ago (1 children)

I just pictured anus teeth chomping at the shit to break it up as you take a crap, and for that, fuck you.

[–] werefreeatlast@lemmy.world 2 points 5 months ago

But functional, you gotta admit 🤪! Or should I say butt?

[–] not_woody_shaw@lemmy.world 1 points 5 months ago

Like that one scene from The Algebraist by Iain M Banks.

[–] ripcord@lemmy.world 4 points 5 months ago

This sounds like great news!