this post was submitted on 23 Jan 2025
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May I see these RCTs please? What do you consider a CVD biomarker? Not LDL hopefully. CAC scores, insulin resistance, or all cause mortality please.
I do not agree with this, a abundance of weak observational studies do not make causation. But the point of this discussion isn't to get us to agree, just to indicate that people well versed in the literature and looking at the evidence strength would not agree that the evidence is overwhelming.. which is to say there has not been a casual link established.
The study Meta-Analysis of Randomized Controlled Trials of Red Meat Consumption in Comparison With Various Comparison Diets on Cardiovascular Risk Factors analyzed 6 RCT's that compared red meat to plant-based protein sources and finds that the plant-based protein sources consistently result in better blood lipids and lipoproteins compared with red meat:
As to your comments about CVD markers, there are of course contrarians, but the evidence linking both LDL-C and apoB with CVD risk is strong. Look at mendelian randomization studies for both.
https://link.springer.com/article/10.1186/s12916-020-01792-7
https://www.neurology.org/doi/full/10.1212/WNL.0000000000007091
https://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1003062
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2814089
Substitution of animal with plant protein lowers apo-B https://www.ahajournals.org/doi/full/10.1161/JAHA.117.006659
In comparison with control diets, plant-based diets improved Homeostatic Model Assessment for Insulin Resistance https://www.mdpi.com/2072-6643/16/13/2110
All cause mortality was reduced by plant-based diet in the meta-analyses of prospective cohort studies I shared earlier, nobody tries to measure that for dietary RCT’s…
Low carb diets high in animal products result in increased CAC scores and the animal-based but not plant-based LCD score is significantly associated with a higher risk of CAC progression (animal-based LCD score: hazard ratio, 1.456 [95% CI, 1.015–2.089]; P=0.041; plant-based LCD score: hazard ratio, 1.016 [95% CI, 0.821–1.257]; P=0.884 https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.120.314838 (observational)