Tl;dw - European empires fucked everything up and we're still living with the aftermath. Plus oil.
Chetzemoka
joined 1 year ago
GOOD. Very proud of my pharmacy colleagues standing up for themselves. More unions, please!
Thanks for the well wishes. Also last year I participated in a clinical trial with this same team at the Brigham. The drug trialed there is called bocidelpar. It targets a mitochondrial receptor called PPAR-δ. We're still waiting on the results of that trial to be released and it's probably a good 3-5 years away from FDA approval in the US if all goes well. So here's hoping for the best
So, the team that I'm seeing at Brigham & Women's in Boston has a testing protocol called invasive cardiopulmonary exercise testing or iCPET, which involves putting a tube into a large vein in the neck, putting a heart catheterization through that, then putting a tube in an artery in the wrist. This allows monitoring and comparison of blood pressures inside the heart vs. outside the heart as well as comparison sampling of arterial blood vs. venous blood. In addition to this, they apply EKG heart monitoring and respiratory monitoring via a gadget you hold in your mouth and breathe through. With all this insanity in place, they put you on an exercise bike until you can't stand it anymore.
What they find on this test is a combination of two things. First, the pressures inside the ventricles of the heart do not increase in response to increased physical activity the way that they should. "Low ventricular filling pressure caused by preload failure." And second, the DEoxygenated blood returning to the heart has too much oxygen in it, indicating poor oxygen uptake on a cellular level, which they hypothesize is caused by mitochondrial problems.
The treatments include a drug called pyridostygmine, which increases acetylcholine neurotransmitter to increase autonomic nervous system response to physical activity (and therefore increase blood return to the heart). Or a drug called midodrine, which also supports blood pressure. Plus supplements to support mitochondrial function like CoQ10, creatine, and ALCAR.
I'm not cured and back to where I was prior to getting sick by any means, but I'm able to hold down a full time job, which prior to treatment I most definitely would not have been able to.
In the same way that your lease doesn't "guarantee" that your landlord will fix the leaking kitchen sink, this is technically true. Which is how they get away with spreading this nonsense.
Nevermind that having that legal contract gives you the only leverage you could possibly hope to have when you take the landlord to court. Same leverage that a union contract gives you over the corporation you work for.
Omg I didn't notice until you pointed it out, but that's exactly the kitchen from Poltergeist.
Someone was clearly living here very recently, just like "This is fine."
Yep, that's a Nebelung if I've ever seen one. So critical haha
Oh definitely and 1000% would never say that productivity is the purpose of life. That perspective is so disgusting, in my opinion. The interactions I have with my patients that bring such satisfaction are the exact opposite of "productive" and frequently put me at odds with the goals of the corporation I have no choice but to work for.
Probably, for me, I'd say my purpose is to lift up people around me. To help them find the ways they are strong and support them through the ways they are weak. Sometimes the only thing I can really do to help someone in the moment is make them laugh, so I try to do that. Sometimes I just sit with them while they cry. Being a nurse just happens to be a profession where I can do this and also receive a paycheck, so it works for me.
I like to picture the world as a scale of good things and bad things. I can't fix all the bad things, but I can add weight to the side of the good things every day. Put one more thing on the good side of the scale and tilt the world in that direction however minutely. I won't tip the whole scale by myself, but my efforts combined with all the other people in the world doing good things that I don't even know about certainly will, even if I personally don't get to witness that tilting.
And that last paragraph is pretty key, in my opinion. Imagination is a fundamental ability of human beings and what we believe about ourselves and the world affects us more than anything external to ourselves. And the way we imagine ourselves and the world is always inherently within our control. So I think part of "what we do" in life is to create meaning.
My Boomer dad bought a ridiculously expensive gaming laptop because he "wanted the best computer" and still believes that more expensive = better. He uses it to surf the internet...🤦
My Boomer dad bought a ridiculously expensive gaming laptop because he "wanted the best computer" and still believes that more expensive = better. He uses it to surf the internet...🤦
Can confirm, there is a condition that removes the air gap causing a pretty much continuous UTI. (Colovesical fistula: https://www.medicalnewstoday.com/articles/colovesical-fistula#treatment-and-management)