69
submitted 1 year ago* (last edited 1 year ago) by SomeoneElse@lemmy.world to c/dontyouknowwhoiam@lemmy.world
top 17 comments
sorted by: hot top controversial new old
[-] justdoit@lemm.ee 12 points 1 year ago

Not to nitpick but to me the title of this post is implying that XXY individuals are born female. Generally they’re born male.

What the comment is referring to is likely Swyer Syndrome, where the individual has an XY configuration but a dysfunctional gene in the sex-determining region of the Y chromosome. This means the embryo develops female anatomy and the resulting children tend to identify female, but they lack functional gonadal tissue. It’s estimated to occur at a rate of about 1 in a 100,000 females.

By the by, treatment for these individuals usually involves removing the dysfunctional gonadal tissue as it often becomes cancerous (which often gets misunderstood as “gender reassignment surgery”) and supplemental hormone replacement therapy. They would be affected too by any bans on hormone administration to kids often connected with trans people. One of the reasons why blanket bans should be a no-go regardless of how you feel about any other trans issue.

[-] coys25@lemmy.world 3 points 1 year ago

Or, androgen insensitivity syndrome, specifically complete androgen insensitivity syndrome:

Androgen insensitivity syndrome (AIS) is a difference in sex development involving hormonal resistance due to androgen receptor dysfunction.

Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens.

The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow female genital and sexual development in those with the condition.

Individuals affected by CAIS develop a normal external female habitus, despite the presence of a Y chromosome, but internally, they will lack a uterus, and the vaginal cavity will be shallow, while the gonads, having been turned into testicles rather than ovaries in the earlier separate process also triggered by their Y chromosome, will remain undescended in the place where the ovaries would have been.

Most individuals with CAIS are raised as females.They are born phenotypically female and are usually heterosexual with a female gender identity; however, at least two case studies have reported male gender identity in individuals with CAIS.

[-] SomeoneElse@lemmy.world 2 points 1 year ago

I think we can safely say that is nitpicking, but it’s informative and correct so I’m all for it!

From my biology lessons 20 years ago, I thought I was taught that it was the presence of a second X chromosome that made a person genetically female, but I could definitely be misremembering. Either way, XXY individuals are usually born male, and Dr Genetics Federation was likely talking about sawyer syndrome (or so google tells me). Thanks for the correction!

[-] justdoit@lemm.ee 1 points 1 year ago

Not in humans, no! While in some animals sex determination is purely about X dosage (Drosophila), in humans the Y chromosome is actually sex-determining. In females the second X chromosome actually gets inactivated as a means of gene dosage compensation.

[-] CreeperODeath@lemmy.world 6 points 1 year ago

I decided to Google it just to be safe

And yes he is lmao

[-] SomeoneElse@lemmy.world 2 points 1 year ago

And 5 time finalist of the Eureka Prize - which sounds impressive even if I’ve never heard of it!

[-] ColonelSanders@lemmy.world 0 points 1 year ago

Just a few letters shy of the acronym PIGFUCKER

[-] ghostface@lemmy.world 3 points 1 year ago

Sometimes people just want to believe what they believe or ignorance is bliss...

[-] DanglingFury@lemmy.world 1 points 1 year ago

Mic drop...

I am curious about the video though

[-] SomeoneElse@lemmy.world 1 points 1 year ago* (last edited 1 year ago)

Transphobic BS I believe. But I’m not trawling through fb to find the original.

[-] UserDoesNotExist@sh.itjust.works 0 points 1 year ago* (last edited 1 year ago)

Is he mixing up people with 3 gonosomes?

Because these are not too rare. It’s one of the more frequent mutations.

But even a person with XXY is a male. Since the male gonosome is considered as a mutation of an X chromosome. Somewhere in the evolution of mammals and other vertebrates (or most likely much earlier) something messed up and created the Y chromosome from an X chromosome. That’s why genetic diseases are usually more frequent in males, since one branch of the X chromosome does not have some backup. It’s simply missing.

So whenever a person has one Y chromosome. It is considered male. The lack of a Y chromosome is considered a female.

This can also be seen in people with genetic disorders, such as three gonosomes. XXX is a female XYY is a male XXY is also a male.

And to everyone’s information: I am for Germany and we do not have two words for sex and gender.

I don’t understand what you English speakers are up to.

[-] justdoit@lemm.ee 2 points 1 year ago

I just wrote a comment above but I believe OP is mixing XXY with what the comment was about, which is likely Swyer Syndrome: XY individuals with female anatomy and gonadal dysgenesis. While they have a Y chromosome, a defective sex-determining gene leads to a failure to sexually differentiate into male gonadal tissue and leads to subsequent loss of downstream sex hormone production.

[-] UserDoesNotExist@sh.itjust.works 0 points 1 year ago* (last edited 1 year ago)

So I assume such people are identified as females at birth. But if their chromosomes indicate that they are male, what’s the gender then?

I think it’s a male then, right? Because when a defect leads to malformations, it still is a malformation. One that people could probably live very well with.

[-] Revan343@lemmy.ca 1 points 1 year ago

If the SRY gene is broken, they'd still physically develop as female, though potentially with some abnormalities, rather than as male. Even leaving gender identity out of it, sex is still more complicated than if exists Y; then male

[-] SLaSZT@kbin.social 1 points 1 year ago* (last edited 1 year ago)

If male and female are assigned purely based on physical anatomy, does it really matter?

No one in that person's life would consider them male and doctors would treat them based on their sex characteristics - they may have testes but they wouldn't be external.

I have never been karyotyped and I'm willing to bet most people haven't either; your sex is assumed based on your outward appearance even when your genitals are not observable.

I really don't think that having a Y chromosome makes you male when you literally have a vagina, you know? Especially when you could go your whole life without knowing.

[-] SomeoneElse@sh.itjust.works 2 points 1 year ago

You had me up to:

And to everyone’s information: I am for Germany and we do not have two words for sex and gender. I don’t understand what you English speakers are up to.

I don’t understand what you mean here? I’m sure biological sex and gender identity are considered separate ideas even in languages without a specific word for them. To my mind a lot of transphobia comes from people not understanding there’s a difference between sex and gender.

As for the XXY, I’m OP and that’s my mistake. I misremembered my biology lessons and thought a second X chromosome made someone biological female, rather than the presence of an Y chromosome making someone male. I replied to someone else explaining my mistake.

[-] 5SpeedDeasil@lemmy.world 2 points 1 year ago

As an English speaker, trust me you don’t wanna know. Don’t dive into it

load more comments
view more: next ›
this post was submitted on 17 Jul 2023
69 points (98.6% liked)

Don’t You Know Who I Am?

3788 readers
1 users here now

Posts of people not realising the person they’re talking to, is the person they’re talking about.

Acceptable examples include:

Discussions on any topic are encouraged but arguements are not welcome in this community. Participate in good faith - don’t be aggressive and don’t argue for arguments sake.

The posts here are not original content, the poster is not OP and doesn’t necessarily agree with or condone the views in the post. The poster is not looking to argue with you about the content in the post.

Rules:

This community follows the rules of the lemmy.world instance and the lemmy.org code of conduct. I’ve summarised them here:

  1. Be civil, remember the human.
  2. No insulting or harassing other members. That includes name calling.
  3. Censor any identifying info of private individuals in the posts. This includes surnames and social media handles.
  4. Respect differences of opinion. Civil discussion/debate is fine, arguing is not. Criticise ideas, not people.
  5. Keep unrequested/unstructured critique to a minimum. If you wish to discuss how this community is run please comment on the stickied post so all meta conversations are in one place.
  6. Remember we have all chosen to be here voluntarily. Respect the spent time and effort people have spent creating posts in order to share something they find amusing with you.
  7. Swearing in general is fine, swearing to insult another commenter isn’t.
  8. No racism, sexism, homophobia, transphobia, xenophobia or any other type of bigotry.
  9. No incitement of violence or promotion of violent ideologies.

Please report comments that break site or community rules to the mods. If you break the rules you’ll receive one warning before being banned from this community.

PLEASE READ LEMMY.ORG’S CITIZEN CODE OF CONDUCT: https://join-lemmy.org/docs/code_of_conduct.html

PLEASE READ LEMMY.WORLD’S CODE OF CONDUCT: https://lemmy.world/legal

founded 1 year ago
MODERATORS