For me it's Corner Gas. I still think it's pretty funny and there's a decent amount of references to Canadian stuff but not enough to be off-putting. I feel like an American wouldn't be confused watching it even if some of the references get a bit dated overtime.
I have only seen a bit of the animated version in waiting rooms.
Kids in the Hall 100%, I know it was popular stateside and if corner gas has dated references, it absolutely does, but it's an absolute classic and some of the recurring bits still pop into my head from time to time.