The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
In real life, you can filter by not hanging out with people who speak abusively about and to you. You can walk away. And yeah, sometimes those abusive people follow you. So a lot of them seek online support communities as a retreat from the abuse. Saying "they should just toughen up" misses on what their daily life is like, and that no one wants to be subject to constant unending abuse