The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
Perhaps that place should be a locked down instance like beehaw, not the public fediverse.
Surely there's a middle ground between "defederating hundreds of instances" and "defederating practically none".