Ask Lemmy

There's a difference between signalling the brain to release its own dopamine and taking external dopamine. (Important note: All of this is a simplification, I am not an expert!)

The first could be done with drugs (legal and illegal) or other dopamine-stimulating activities with instant rewards, and it absolutely has the ability to change our reasoning (like "Oh yeah, I'll definitely feel better if I sit motionlessly for hours scrolling memes I don't even find that funny, and should not, as logic and knowledge dictates, maybe go outside and move my body a little, because that won't feel as good (doesn't release as much dopamine)"). So here, the answer is yes, totally. Which is why for example ADHD medication tries to effect an easier release of dopamine to make it easier on the brain-carrier to make different choices, away from instant reward towards delayed gratification.

For the second thing - dopamine's precursor, L-Dopa, is the straightest way to actually add more dopamine to the brain (since dopamine itself can not pass the blood-brain-barrier, but L-dopa can and is then synthesized into dopamine), which is done in Parkinson's patients and helps them tremendously. Interestingly however, if you overdose it, you can fall into a drug-induced psychosis, a state in which one could argue that logic and reasoning are indeed affected, so that's another yes, but not in the way you mean, I think.

In conclusion, brain neurotransmitter chemistry is pretty complicated, but interesting, and the answer to the question if changing something about it will lead to different ways of thinking is very often yes, which is why medicine is doing it :)