Israel has signed but not ratified the Chemical Weapons Convention (CWC).[18] In 1983 a report by the CIA stated that Israel, after "finding itself surrounded by frontline Arab states with budding CW capabilities, became increasingly conscious of its vulnerability to chemical attack... undertook a program of chemical warfare preparations in both offensive and protective areas... In late 1982 a probable CW nerve agent production facility and a storage facility were identified at the Dimona Sensitive Storage Area in the Negev Desert. Other CW agent production is believed to exist within a well-developed Israeli chemical industry."[19][20]

There are also speculations that a chemical weapons program might be located at the Israel Institute for Biological Research (IIBR[21]) in Ness Ziona.[22]

190 liters of dimethyl methylphosphonate, a CWC schedule 2 chemical used in the synthesis of sarin nerve gas, was discovered in the cargo of El Al Flight 1862 after it crashed in 1992 en route to Tel Aviv. Israel said the material was non-toxic and was to have been used to test filters that protect against chemical weapons. It had also been clearly listed on the cargo manifest in accordance with international regulations. The shipment was from a U.S. chemical plant to the IIBR under a U.S. Department of Commerce license.[23]

In 1993, the U.S. Congress Office of Technology Assessment WMD proliferation assessment recorded Israel as a country generally reported as having undeclared offensive chemical warfare capabilities.[2] Former US deputy assistant secretary of defense responsible for chemical and biological defense Dr. Bill Richardson said in 1998 "I have no doubt that Israel has worked on both chemical and biological offensive things for a long time... There's no doubt they've had stuff for years.