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Superbugs are on the rise. How can we prevent antibiotics from becoming obsolete?
(www.livescience.com)
this post was submitted on 02 Oct 2023
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Wasn't there a whole thing about bacteriophage treatment and supplement to antibiotics?
Like, "if bacteria develop resistance to one it reduces resistance to the other!" kinda deal?
Long story short: bacteriophage are extremely difficult to fit in the current legal/regulatory framework of the medical/pharma world/system.
Bacteriophage are not stable compounds such as chemical molecules (antibiotics, etc...). They evolve and change, adapting to bacterial evolution (or just spontaneously because we're talking about organisms, who sometimes just changes). It may be an advantage from a efficacity point of view, buts it's a big no-no from a regulation point of view.
This makes is harder to have real trials (even if things progress slowly).
Then you have all the biological questions about injecting live virus in an patient and the risk of immune response.
Then you have the complexity of both producing phages in a stable manner (remember: these fuckers have a tendcy to "evolve" on their own) as well as shipping them (require refrigeration all the way, contrary to antibiotic pills).
Source: bacteriophage were the subject of my master thesis, even if it was a while ago.