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I concede that very few people bother to learn the sequence or create a keybinding to symbols used at school. However, every keyboard that has a searchable emoji picker should also index the rest of Unicode in my opinion.

Custom keybindings I use the most are (in no particular order) πµΩαβγΔ²³±√∞≤≥≠∈⋮⌀∙█⚠☢☣♥⚙✔✖❗←↑→↓·ẞ, nbsp and hair space. There is also ☃ (Shift+AltGr+8) as an XKCD reference.