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Sleeping pills stop the brain’s system for cleaning out waste (arstechnica.com)

submitted 8 hours ago by pelespirit@sh.itjust.works to c/science@mander.xyz

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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[–] RobotToaster@mander.xyz 20 points 7 hours ago (3 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] __nobodynowhere@lemm.ee 3 points 7 hours ago (2 children)

What about Benadryl?

[–] rickyrigatoni@lemm.ee 12 points 5 hours ago

The hat man cleans your brain for you.

[–] RobotToaster@mander.xyz 4 points 5 hours ago

Unknown, but it's an anticholinergic, and those are associated with dementia.