Kind of feels disparate from it being a video game, but it's difficult to really make this experience another way:
I wanted to play a healer in an MMO. It was a shitty MMO, so healers could only be female characters wearing skimpy armor.
Well, it took about half a minute until I had people walk up to me, to then just stop 3 meters away. From the way they were moving, I have to assume, they were working their cameras to look underneath my skirt, and probably doing so with only one hand.
Some of them were sending me "hello :)" messages, which I guess is basic decency, if you're going to use my body, but it felt weird, too, since we had nothing to talk about.
All in all, it felt uncomfortable. And I did not even have to fear for them to start touching or even raping me. Plus, I was able to log out, delete my account and basically just leave all of that behind.
Well, except for one thing I did not leave behind: I do not want to be the other side in that experience either.
There's a comic, titled "Loss", which is infamous, because it's incredibly fucking depressive. People don't enjoy being reminded of it. And so, of course, it has become an internet culture / meme thing to do precisely that, but in a sneaky way.
In particular, the comic has 4 panels and an arrangement of characters in a certain, recognizable pattern. So, over time, it's been reduced ad absurdum to just this pattern.
Well, and in the meme above, it becomes apparent that it's replicating the Loss pattern, when that fourth panel has the DNA flipped on its side. So, the joke is that we have the pattern-seeking brain for recognizing Loss.