What amp sim? What cab IR?
Active or passive pickups?
Does the DI / audio interface have Hi Z input?
Does it sound lifeless if you record/listen to the sound straight from the DI?
My guess is it’s the impedance. If you’ve got a guitar stompbox pedal kicking about, one that doesn’t have true bypass, put your guitar into that and then into your DI and see if the life comes back (don’t engage the effect).
Motu’ Zbox can be a game changer if your interface doesn’t offer decent Hi Z inputs to give you the impedance you need.